--- title: Helping MRIGlobal Bring the Lab to the Sample description: MRIGlobal has been designing and building modular systems for real-time detection, diagnosis, and biosurveillance of emerging infectious diseases. image: https://blog.biomeme.com/hubfs/Biomeme%20two3%20device.png --- [![logo](https://blog.biomeme.com/hubfs/logo.svg)](https://biomeme.com) - [Applications](https://biomeme.com/applications) - [Host Response Rapidly analyze host immune responses](https://biomeme.com/applications/host-response) - [Our Evidence](https://biomeme.com/applications/host-response/our-evidence) - [Infectious Disease Detect and identify infectious agents quickly](https://biomeme.com/applications/infectious-disease) - [Pandemic Preparedness](https://biomeme.com/applications/infectious-disease/pandemic-preparedness) - [Biodefense Secure and reliable testing for biodefense applications](https://biomeme.com/cbrn-solutions) - [Biowarfare Detection Suite](https://biomeme.com/biowarfare-detection-suite) - [Solutions by Sector](https://biomeme.com/solutions-by-sector) - [Researchers Portable and efficient testing for remote areas](https://biomeme.com/applications/researchers) - [Platforms](https://biomeme.com/platforms) - [Franklin ISP](https://biomeme.com/platforms/franklin-isp) - [Franklin](https://biomeme.com/platforms/franklin) - [Our Vision](https://biomeme.com/our-vision) - [One Health](https://biomeme.com/our-vision/one-health) - [Antimicrobial Resistance](https://biomeme.com/our-vision/antimicrobial-resistance) - [Antibiotic Resistance](https://biomeme.com/our-vision/antimicrobial-resistance/antibiotic-resistance) - [Antimicrobial Stewardship](https://biomeme.com/our-vision/antimicrobial-stewardship) - [Host Response](https://biomeme.com/our-vision/host-response) - [Layman's View](https://biomeme.com/our-vision/host-response/understanding-host-response) - [Support](https://help.biomeme.com/) - [About](https://biomeme.com/about) - [Careers](https://biomeme.com/careers) - [Leadership](https://biomeme.com/about/leadership) - [Scientific Advisory Board](https://biomeme.com/scientific-advisory-board) - [Insights](https://blog.biomeme.com/) - [Contact Us](https://biomeme.com/about/contact) [![logo](https://blog.biomeme.com/hubfs/logo.svg)](https://biomeme.com) - [Applications](https://biomeme.com/applications) - [Host Response](https://biomeme.com/applications/host-response) - [Our Evidence](https://biomeme.com/applications/host-response/our-evidence) - [Infectious Disease](https://biomeme.com/applications/infectious-disease) - [Pandemic Preparedness](https://biomeme.com/applications/infectious-disease/pandemic-preparedness) - [Biodefense](https://biomeme.com/cbrn-solutions) - [Biowarfare Detection Suite](https://biomeme.com/biowarfare-detection-suite) - [Solutions by Sector](https://biomeme.com/solutions-by-sector) - [Researchers](https://biomeme.com/applications/researchers) - [Platforms](https://biomeme.com/platforms) - [Franklin ISP](https://biomeme.com/platforms/franklin-isp) - [Franklin](https://biomeme.com/platforms/franklin) - [Our Vision](https://biomeme.com/our-vision) - [One Health](https://biomeme.com/our-vision/one-health) - [Antimicrobial Resistance](https://biomeme.com/our-vision/antimicrobial-resistance) - [Antibiotic Resistance](https://biomeme.com/our-vision/antimicrobial-resistance/antibiotic-resistance) - [Antimicrobial Stewardship](https://biomeme.com/our-vision/antimicrobial-stewardship) - [Host Response](https://biomeme.com/our-vision/host-response) - [Layman's View](https://biomeme.com/our-vision/host-response/understanding-host-response) - [Support](https://help.biomeme.com/) - [About](https://biomeme.com/about) - [Careers](https://biomeme.com/careers) - [Leadership](https://biomeme.com/about/leadership) - [Scientific Advisory Board](https://biomeme.com/scientific-advisory-board) - [Insights](https://blog.biomeme.com/) - [Contact Us](https://biomeme.com/about/contact) # Helping MRIGlobal Bring the Lab to the Sample ![](https://blog.biomeme.com/hubfs/Biomeme%20two3%20device.png) **Written By:** Biomeme Staff #### [Joe Russell](https://www.linkedin.com/in/joe-russell-686abab/) and [Jonathan Jacobs](https://www.linkedin.com/in/jonathanjacobs/) at MRIGlobal have been designing and building modular systems for real-time, point-of-care molecular microbiology. Recently developed molecular analysis platforms offer the promise of bringing comprehensive detection, diagnostics, and biosurveillance of emerging infectious diseases to extremely remote and austere locations, completely detached from a traditional brick and mortar laboratory. [![MRIGlobal Poster](https://blog.biomeme.com/hs-fs/hubfs/Imported_Blog_Media/MercuryLab_ASM_Biothreats_2017-1-1.png?width=1131&height=896&name=MercuryLab_ASM_Biothreats_2017-1-1.png)](http://biomeme.com/wp-content/uploads/2017/02/MercuryLab_ASM_Biothreats_2017-1.pdf) MRIGlobal's poster presentation detailing the Mercury Lab Technology in collaboration with Biomeme.   Joe and Jonathan recently field tested one of their “Mercury Lab” prototypes in the first demonstration, to our knowledge, of direct, non-PCR-based, metatranscriptomic detection of an RNA virus from mosquitoes using nanopore sequencing. This work shows the feasibility of a backpack-enabled workflow for field-able, genomics-based biosurveillance. Read more about the Mercury Lab on [MRIGlobal's poster presentation](http://biomeme.com/wp-content/uploads/2017/02/MercuryLab_ASM_Biothreats_2017-1.pdf).   Biomeme’s two3 mobile handheld qPCR machine and the MinION from Oxford Nanopore Technologies offer target amplification and long-read sequencing capability, respectively, in an ultracompact form factor that is amenable to transport and use by a single operator. Additionally, Biomeme offers nucleic acid extraction kits that can be adapted to different matrices, do not require pipettes, and can be completed in just a few minutes.   The MRIGlobal team field tested a combination of these technologies in an arbovirus surveillance project monitoring Culex cedecei mosquitoes captured at several sites near Everglades National Park. MRIGlobal’s results demonstrated: - Robust extraction of RNA from mosquito pools for purposes of arbovirus surveillance using Biomeme’s ultra portable Bulk Nucleic Acid Extraction kit (mean RNA concentration from 25 mosquito pool: 1.02 ng/μl). - Effective detection of low-titer arbovirus (Everglades Virus) from single 25-mosquito sample pool using Biomeme two3 qPCR thermocycler. Results comparable to current ‘gold standard’ qPCR platforms. - Nanopore sequencing capable of detecting RNA virus from complex sample matrix after eukaryote rRNA depletion and whole transcriptome amplification reaction. **UPDATE** We are excited to announce that this work has been featured in the GenomeWeb article, "MRIGlobal Demonstrates Nanopore Sequencing in the Field in Step Toward 'Lab-in-a-Backpack'" by Monica Heger. GenomeWeb is an independent online news organization the serves the global community of scientists, technology professionals, and executives who use and develop the latest advanced tools in molecular biology research and molecular diagnostics. [To read the full article on genomeweb follow this link](https://www.genomeweb.com/sequencing/mriglobal-demonstrates-nanopore-sequencing-field-step-toward-lab-backpack) (Subscription required)   Have an application for this technology? Please [contact us](https://biomeme.com/contact-us). #### Subscribe Now Get the latest tips from Biomeme shipped right to your inbox ## Related Blog Posts [![](https://blog.biomeme.com/hubfs/DoD%20Partnership.png)](https://blog.biomeme.com/biomeme-on-the-front-lines) [Explained](https://blog.biomeme.com/tag/explained) ### Biomeme on the Front Lines The landscape of modern warfare is undergoing rapid transformation. 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